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Once inside the muscle, creatine is converted into phosphocreatine , which helps form adenosine triphosphate (ATP) your bodys immediate and primary energy source

Food Chem Toxicol 62:671683 Aruoma OI, Murcia A, Butler J, Halliwell B (1993) Evaluation of the antioxidant and proantioxidant actions of gallic acid and its derivatives

They're implying that this gut serotonin is affecting brain, the brain directly, but it actually serotonin can't cross the blood brain barrier

274 Prion diseases are caused by accumulation of a pathological prion, known as Prion PrP Sc , which are misfolded polypepetides converted form physiologically significant cell-surface glycoprotein PrP C encoded by the PRNP gene

Ansari et al., 2015