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Activation of CB1R by THC disrupts the balance between excitatory and inhibitory neurotransmission, particularly affecting GABAergic and glutamatergic systems (Castelli et al., 2023a

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For example, in fish GPX4 activity contributes to a greater extent to total GPX activity, [19] GPX4a is the most highly expressed selenoprotein mRNA (in contrast to mammals where it is GPX1 mRNA) [20] and GPX4a appears to be highly inducible to changes within the cellular environment, such as changes in methylmercury and selenium status

A study in mice suggested that coadministration of chlorpropamide or tolbutamide with alcohol resulted in inhibition of ALDH2, chlorpropamide being relatively more potent