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Pregnancy and breastfeeding lack strong safety data, so avoid unless your clinician advises

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B cells, which are derived from pluripotent stem cells in the bone marrow, differentiate into plasma cells upon antigen stimulation and are responsible for humoral immunity through the secretion of immunoglobulins such as IgG, IgA, and IgM

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Healthcare providers should watch for B12 deficiency in these patients

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Peer review Peer review information Communications Biology thanks Anna Feix and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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Introduction Cardiovascular disease (CVD) remains the leading cause of debility and premature death (WHO, 2013), and hence a major public health problem

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