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Common symptoms include: Extreme fatigue that is not relieved by rest Post-exertional malaise: worsening of symptoms after physical or mental activity Sleep problems: unrefreshing sleep, insomnia, or other sleep disturbances Cognitive difficulties: problems with memory, focus, and concentration (often referred to as "brain fog") Muscle or joint pain Headaches Sore throat Tender lymph nodes Dizziness that worsens with moving from lying down or sitting to standing Causes and Risk Factors The exact cause of CFS is unknown, but it is believed to result from a combination of factors: Genetics: A family history of CFS or other autoimmune diseases can increase the risk

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In other genetic disorders, there are now algorithms aiming to estimate the probability that a particular previously unknown mutation is or is not pathogenic

As a clinician working with high level athletes in Colorado Springs, I have seen a number of patients who are interested in these compounds or who are actually taking them