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Introduction Fibrosis is characterized by exuberant extracellular matrix (ECM) protein deposition in the basement membrane and interstitial tissue in the setting of an injured overlying epithelium and expansion of activated mesenchymal cells (myofibroblasts)

The thiomethylation pathway (shunt) (see Thiomethyl Shunt section) for the detoxification of xenobiotics was first elucidated by Tateishi and colleagues

If that sounds familiar, youre definitely not alone

doi: 10.1016/j.febslet.2005.04.058

Owing to seasonal variations in the occurrence of this disease, it was suggested that a viral cofactor, such as myocarditic strains of the Coxsackie virus, may contribute to disease onset