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The essential oil diminishes the cell integrity, increases permeability, and distorts membrane permeability

Kusumi, M., Nakashima, K., Harada, H., Nakayama, H
Exposure to CSE perturbed the formation of tight junctions, leading to an increase in cell volume, a decrease in transepithelial electrical resistance (TER) in the human corneal epithelial cell-transformed (HCE-T) cell line

In the elderly, hypothyroidism is associated with accelerated cognitive decline and an increased risk of Alzheimer's disease, raising the possibility that impaired thyroid signaling may act as a modifiable risk factor for dementia (83)
Metformin (Cat# AG-CR1-3689) was acquired from AdipoGen Life Sciences (San Diego, California, USA) and dissolved in HPLC water
