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: diabetic patients at 0 weeks (n = 38), : diabetic patients at 8 weeks (n = 38), : non-diabetic subjects at 0 and 8 weeks (n = 23)

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This review was carried out by searching on the electronic databases (including PubMed, ScienceDirect, and Pubchem) for studies focusing on the molecular mechanism of berberine in the biological processes related to neurodegenerative diseases

Virus-induced HMRD in tandem with hypoxia and m- Dys affects several cellular metabolic pathways in COVID-19 survivors (after viral clearance), which could ultimately evoke severe PASC with metabolic impairments including new onset T2DM, cardiovascular disease, chronic fatigue syndrome, brain fog, and blood clotting issues 21,143

Studies have shown that the hexosamine pathway plays a role in mediating ROS-induced toxicity under hyperglycemic conditions (34, 35)