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In fact, GSH depletion obtained by BSO, the irreversible inhibitor of GCL, is the most frequently used approach and it is associated with many chemotherapeutic agents [5357]

Other genetically modified BCAs can produce different substances like Vitamin C, which can silence the gene clusters responsible for mycotoxin productions

Nicotinic acid doses above 50 mg/day usually trigger flushing and itching within 30 minutes after taking it [6]

Since ROS-dependent DNA damage is markedly increased in myeloid cells after Bcr-Abl transformation 18 , we hypothesize that blocking dTTP and dCTP supply might exacerbate replication stress and DNA damage in Bcr-Abl-transformed cells, thereby jeopardizing cell survival