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Description
Proton magnetic resonance spectroscopy (1H-MRS) can assess alterations in brain neurochemical profile non-invasively in vivo over time

In this study, we reveal a cysteine-reactive covalent ligand EN25 that covalently targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL, leading to inhibition of GCL activity, lowering of cellular GSH levels, and impaired cell viability in ARID1A-deficient cancer cells that are particularly vulnerable to glutathione depletion, but not in ARID1A-positive cancer cells

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Collectively, ATRA-ATO-NPs offer a mechanistically targeted, systemically safe, and highly effective strategy for advanced oncotherapy through dual-site spatiotemporal and simultaneous Pin1 inhibition
Why Preparation MattersL-carnitine solutions are sensitive to environmental factors such as:Oxygen exposureLightTemperaturePH These variables can influence clarity, consistency, and stability over time
