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Indirect evidence supporting a possible benefit of methylation cycle supplements include findings of increased homocysteine in the cerebrospinal fluid of CFS and fibromyalgia patients

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This has been referred to as a paradoxical vitamin B12 deficiency, because the B12 is functionally unavailable

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2) Sequential duallock: aPS contains two bioresponsive moieties linked in a sequential manner, requiring activation at the first site to enable subsequent activation at the second, thus unlocking the photosensitizer in a stepwise process