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In another study published by this group, PROTAC AK-2292 demonstrated potent cytotoxic activity against a panel of chronic myeloid leukemia (CML) cells, with IC 50 values around 0.2 to 2.2 M, as well as potent antitumor activity in xenograft tumor tissues of human CML NCO2 and KU812 cell lines in mice

Finally, there are other neurotrophic factors that have shown dopaminergical neuronal protection in Parkinson-like models, including hepatocyte growth factor (HGF), mesencephalic astrocyte-derived neurotrophic factor (MANF), cerebral dopaminergic neurotrophic factor (CDNF), granulocyte colony-stimulating factor (G-CSF), and platelet derived growth factor (PDGF-CC) [31-32, 135-136]

Hydrolea zeylanica improves cognitive impairment in high-fat diet fed-streptozotocin-induced diabetic encephalopathy in rats via regulating oxidative stress, neuroinflammation, and neurotransmission in brain

Levels of GGT decrease with supplemental NAC or whey protein, reducing the need to recycle GSH (Pizzorno 2014)

San Diego, 2/28/2015 Update on Spine Registries