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Limited Clinical Safety Data : The human safety profile remains unclear because the evidence is primarily based on animal and laboratory studies rather than large-scale clinical trials

-Arrestin2 -knockout mice (Jax Stock No: 011130) were obtained from Gang Pei

Notably, genes promoting glutathione biosynthesis were broadly upregulated, whereas genes associated with glutathione consumption or turnover were comparatively reduced ( Figure 6B )

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