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Forward thinking nutritionists have argued for rising B12 requirements and updating the lab test cutoff point for B12 deficiency

Metabolism 63, 104111
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Such tissue changes may involve alterations in myelination 179 , pathological protein accumulation 180 , or changes in concentrations of other magnetically-reactive metals such as calcium, copper, and magnesium 179

He calls these "longevity vitamins," and he has placed ergothioneine squarely in this category
