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What are the Neurological Symptoms of Vitamin B12 Deficiency

Those with MTHFR gene mutations lack the enzyme required to activate folic acid, which can result in a buildup of unmetabolized folic acid (UMFA)

One patient was reported to have learning disability with dyslexia and was also thought to be mentally retarded [5], and another had delayed psychomotor development and progressive sensory neuropathy of lower extremities, ataxia, hyperreflexia, dysarthria, and a peculiar gait suggestive of spinocerebellar degeneration [2]

When to Consider Vitamin B12 Treatment If symptoms continue or become more severe, starting Vitamin B12 treatment can correct deficiency, improve symptoms, and support overall health

In the first two studies, changes in redox and methylation metabolism were reported but because the studies were open-label the changes in these biomarkers were not compared to a placebo group