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Inhibition of the mTOR pathway significantly reduces the inflammatory response in microglia, highlighting how cellular metabolic pathways, particularly the mTOR-HIF-1 pathway, can influence the functional phenotype of microglia (Cheng et al., 2014)

High homocysteine levels are associated with vascular damage, neuroinflammation, and synaptic dysfunction, all of which contribute to cognitive decline [36]

van Dam & Feskens 2002)

However, in the face of chronic, complex illness, this vital defense mechanism can become profoundly overwhelmed and depleted

HSF1 pathway inhibitor clinical candidate (CCT361814/NXP800) developed from a phenotypic screen as a potential treatment for refractory ovarian cancer and other malignancies