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(1995) Targeted disruption of the 3-adrenergic receptor gene

These findings have generated hypotheses for future investigation, but they should not be interpreted as demonstrating established clinical benefits in humans

Studies have shown that HO-1 may be involved in the development of diabetic complications like diabetic kidney, diabetic cardiovascular disease, and diabetic wound healing

Moreover, ATRA activates the Nrf2-based pathway, as well as enhances skin resilience to oxidative stress by preventing Nrf2 degradation and modulating genes involved in antioxidant defense, such as SOD and CAT 181

doi: 10.1530/jrf.0.0560439