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However, knocking down GPX7 in LX-2 cells increases the synthesis of profibrotic and pro-inflammatory genes and collagen (Kim et al., 2020)

10.1021/ja0367703

2022 Dec 14;13:1026182

For these reasons, many clinical trials have evaluated the efficacy of N -acetylcysteine (NAC) administration, and many are still ongoing (714 studies, 349 completed), as well as the effects of GSH supplementation (162 studies, 100 completed) ( NAC is both a thiol with antioxidant properties and one of the substrates in GSH biosynthesis
