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c , The cytoplasmic C-terminal domain of TMEFF1 (TMEFF1-C) was expressed in bacteria fused to Glutathione-S-transferase (GST)

Increased proton pump expression in oesophageal tissue may also contribute to local acid secretion, causing inflammation, mitochondrial damage and, ultimately, carcinogenesis (Reference Stabenau, Samuels and Lam31)

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Chlorpromazines antiprion MoA was largely unspeculated-upon until 2014, when a crystal structure was published showing chlorpromazine bound to PrP C [Baral 2014]

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