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doi: 10.1016/S0021-9150(00)00739-5

The Science Behind Successful Peptide Reconstitution 5
Thus, genome edited plants are increasingly displacing mutants with T-DNA insertions, and the CRISPR/Cas9 genome editing system has become widely used in applied research to create crops with valuable agronomic traits without introducing exogenous sequences and with minimal off-target changes in the genome [13,14]

Safety and long-term effects are still topics of scientific investigation
