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NephroGenex reached agreement with the FDA in 2013 on a Special Protocol Assessment (SPA) for the PIONEER clinical program, and received Fast Track designation by the FDA for Pyridorin in diabetic nephropathy dating July 2002 (22)

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Notably, several of the pro-inflammatory cytokines known to upregulate CD38 expression, including IL-6, interferons, TGF-, as well as SASP, are also implicated in SSc 2

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