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Devices such as the xCELLigence System [40] and the wMicroTracker System [24, 37] have been validated for high-throughput drug screening with Caenorhabditis elegans and a few parasitic helminth species, yet the readout is limited entirely to locomotion activity

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This is further supported by the finding of significantly increased genes involved in regulating cellular responses to hypoxic environments in primary SS patients minor salivary glands containing IL-21 (194)

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