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Additionally, nanoparticles possess advantages such as small particle size, high drug loading capacity, controlled drug release, efficient tumor targeting ability, and prolonged in vivo circulation time (142)

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Additionally, cultured RPE cells can bidirectionally transport glutathione (Lu et al., 1995), exhibit polarized transport mechanisms (Li et al., 2011) and possess a Na+-dependent transport mechanism on the apical surface of non-transformed human RPE cultures (Kannan et al., 2001), but it remains unknown what role this plays in the retina in vivo (Davidson et al., 1995

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