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Description
McNulty, Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation
AduCPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood

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UA activates the inflammatory response of tissue-intrinsic cells indirectly affecting immune cells MSU crystals activate the TLR4/NF-B/NLRP3 signaling pathway in human umbilical vein endothelial cells (HUVECs), leading to the secretion of intercellular cell adhesion molecule-1 (ICAM-1), IL-1, IL-6, and vascular cellular adhesion molecule-1 (VCAM-1)