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Mitochondria uses GSH as a respiratory substrate at high pH, in the presence of Ca 2+ or Mg 2+ , while at pH 7.0, in the presence of EDTA, GSH does not increase the O 2 consumption of mitochondria

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Steroidogenic acute regulatory protein (StAR) does not appear to affect the MC2 promoter but regulates steroidogenesis, an effect augmented by ACTH via the MC2R

Some of those effectors include endocannabinoids, eicosanoids, cytokines, and transcription factors