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Second, Nrf2 upregulation increases cell proliferation and this is accompanied by hyperphosphorylation of retinoblastoma protein, possibly brought about by increased activity of the cyclin D1/CDK4/CDK6 complex and the cyclin E/CDK2 complex that has been speculated to be a consequence of repression of p21 expression [420]

Ethics statement Use of human erythrocytes was approved by the La Trobe University Research Ethics Committee (ethics number HEC17013) and an Australian Red Cross Blood Service Agreement (Deed 19-05VIC76 01)

After 30 days, behavioral tests using the plus maze were conducted, and cortisol and IL-17 levels were measured via ELISA

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