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Blood serum APAP concentrations measured in these patients ranged from 4 to 284 mg/L (median 52 mg/L), and correlated positively with APAP signals measured with the HRMS-based method (r 2 = 0.89, table S7)

32 After the sample is collected, erythrocyte and platelet metabolism persist in vitro , and ammonia concentrations increase when kept at room temperature

Specifically, copper's ability to enhance MMP expression, particularly MMP-1, which regulates collagen breakdown, might lead to a temporary increase in cellular debris or a transient inflammatory response as the skin purges and rebuilds

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