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Specifically, single-target drugs are often limited by insufficient efficacy, rapid development of resistance, and significant side effects (Han Li and Chen, 2015

Artesunate exerts protective effects against ulcerative colitis via suppressing Toll-like receptor 4 and its downstream nuclear factor-kappa B signaling pathways

Interestingly, a number of intracellular proteins that can be released and act as endogenous inflammatory signalling molecules (also known as damage-associated molecular patterns) can undergo glutathionylation, including high mobility group box 1 protein (HMGB-1) 14 , proteins of the S100 family 15 , galectin-1 16 , peroxiredoxin-2 (Prdx2) 17 and heat-shock protein 70 (HSP70) 18

Glutathione system 2.1 Structure and functions of the glutathione system Glutathione, -glutamyl-cysteinyl-glycine (GSH), is a ubiquitous intracellular tripeptide present in all mammalian tissues, especially in the liver

The macrophage-inducible calcium-dependent lectin receptor (MINCLE) is induced by lipid signals from tumor cells, which facilitate the activation of the IRE1-XBP1s pathway in macrophages