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and, taking their submissions into consideration to revise the draft, followed by review by the Agencys Health, Medical and Research (HMR) Committee.

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The underlying mechanisms of NO action may rely on its reactivity with different kinds of biomolecules, leading to modulation of enzymatic activities, and of gene transcription, with profound impact on metabolism and signal transduction pathways

Liver function markers (ALT, TBIL, AST, ALB), fibrosis markers (HA, PC III, LN), and liver fibrosis grades were assessed pre-and post-treatment