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Additionally, cytosine arabinoside (Ara-c) combined with CB-839 or BPTES inhibited the proliferation of leukemic cells more strongly than that of monotherapy [5, 17]

Although some transport of glutathione S -conjugates may occur across the sinusoidal membranes (e.g., Inoue et al., 1984a, Inoue et al., 1984b), the major route for the removal of these compounds in the rat liver is via canicular transporters into the bile (e.g., Akerboom et al., 1991, Hinchman et al., 1998, Keppler and Knig, 2000, Vore, 1993)

Within weeks, many patients notice decreased pain, improved stability, and increased range of motion

Although the precise methanism(s) are not known with certainty, the result is subacute combined degeneration of central nervous system and spinal cord