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Specifically, the malate/aspartate shuttle proteins MDH2, -KG/malate carrier, and GOT2 were found to be hyperacetylated leading to suppression of the transport and oxidation of cytosolic NADH in mitochondria, which correlated with decreases in oxygen consumption and cardiac energetics (manifested by a reduction in phosphocreatine/ATP) (42, 47)
Wang C, Zhao M, Liu Y-R, Luan X, Guan Y-Y, Lu Q, et al
Kumar AN, Naidu JN, Satyanarayana U, Anitha M, Ramalingam K
RNAi For RNA interference, siRNA duplexes were synthesized in GenePharma
Trends in Biochemical Sciences, 16, 112115
