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To define whether paclitaxel induces the activation or the inhibition of C5aR1 through its binding, we then performed a cell-based cAMP assay in single dose experiments and found that paclitaxel can activate, but not inhibit, C5aR1, while dose-response experiments showed that paclitaxel EC 50 is 5.81 M and Emax around 50%, demonstrating that paclitaxel is a new partial agonist of C5aR1 (Fig
Immunohorizons 6 , 476487 (2022)
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