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Consistent with the reduced in vitro binding, in TFG-depleted HEK293T cells reconstituted with exogenous TFG constructs, both PB1-deleted and CC-deleted TFG failed to support lysosomal CHMP4BmNG recruitment upon LLOMe treatment (Extended Data Fig

To further investigate the KEGG pathways in CM10-CM14, gene set enrichment analysis revealed significant roles in protein folding, cellular signaling, and stress response, highlighting pathways such as Protein processing in endoplasmic reticulum, Glutathione metabolism, and Plant hormone signal transduction. (Fig

doi: 10.1111/bjd.17092 202 SaxenaMYeretssianG

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