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Metabolism 118 , 154739 (2021)

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However, the cellular array of ROS-dependent, redox-sensitive MCS is not limited to the MAM: While the ER may be the most significant ROS producer in some cell types, as assayed by fluorescent probes 20 , and mitochondria are well known producers of ROS via oxidative phosphorylation 21 , peroxisomes are another source of ROS 22 (summarized in Table 1)