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Similarly, CD276, a member of the B7 family, not only hinders the infiltration of CD8 + T cells into the tumor microenvironment, but also promotes T cell exhaustion by downregulating the secretion of key cytokines, such as IFN- (93)
PAM catalyses the cleavage of glycine, resulting in a bioactive C-terminal amidated peptide and glycoxylate (Bradbury & Smyth, 1991

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