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doi:10.1079/BJN19940043

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The innate immune system, including natural killer (NK) cells, tumor-associated macrophages (TAM), myeloid-derived suppressor cells (MDSC), dendritic cells (DCs), and granulocytes, acts as the bodys first line of defense and bridge to adaptive immunity ( + T cells, NK cells are critical effector cells to control tumor growth in both hematologic malignancies and solid tumors

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Nef also activates NADPH oxidase through the Vav/Rac/PAK pathway in phagocytes, amplifying neuroinflammation and promoting myelin injury and neuronal damage [134, 140]