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A study in adults aged 70 and older showed increased heteroplasmy linked to an increased depression score.[ref] Rare mitochondrial mutations that cause mitochondrial diseases are also linked to major depressive disorder.[ref] In fact, one study of people with hereditary (genetic) mitochondrial diseases showed that 54% had major depressive disorder and 17% had bipolar disorder.[ref] Outside of the mitochondrial genome, genes in the nuclear genome that code for proteins in the mitochondria are also linked to depression

Yes, its recommended to be hydrated and have a light meal beforehand to help you feel your best during treatment

Estrogens are mainly produced in the ovaries, the placenta in females, and the adrenal cortex of males, and are retained in target cells by estrogen receptors (ERs) [83]

Chew BP, Mathison BD, Hayek MG, Massimino S, Reinhart GA, Park JS (2011) Dietary astaxanthin enhances immune response in dogs