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Woitalla D

NGRA aims to conduct safety assessments that are human-relevant, exposure-led, hypothesis-driven and designed to prevent harm ( in vitro bioactivity at human-relevant concentrations and, consequently, adverse health effects, in lieu of replicating apical endpoints that would traditionally be obtained using high-dose animal studies (OECD, 2017

One of the concerns with any rapid weight loss, whether from GLP-1 medications, calorie restriction, or surgery, is the loss of lean body mass alongside fat

Lancet 405 (10474), 241256

The science is still developing and it's a space worth watching rather than packing over
