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In addition to its role in the synthesis of cysteine, methionine is critical in the synthesis of the methyl donor, S-adenosylmethionine (SAM, SAMe, or AdoMet)

Schwalfenberg, 2021)

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Furthermore, in this study, patient selection was very careful, intraocular fluid was harvested without touching any intraocular tissues, and LC-ESI-MS/MS was used, which is a very sensitive metabolomic technique in small samples

While App knockin mouse shows no significant neurodegeneration and neuronal loss, it shows synaptic loss and reduction of a part of neuronal cells including active place cells around A plaques 41,60