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Metastasis progression and therapeutic resistance usually occur due to the presence of rare clones in primary tumors

Anaraki SR, Aali Y, Nikbaf-Shandiz M, et al

Exp Mol Pathol 132:104866 Infante M, Ricordi C,Sanchez J, Clare-Salzler MJ, Padilla N, Fuenmayor V, Chavez C, Alvarez A, Baidal D, Alejandro R, Caprio M

Challenges in effective management While treatment with hydroxocobalamin is effective in most cases, some patients may continue to experience symptoms (particularly neurological symptoms and fatigue)[27]
