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Single-cell transcriptomics and functional assays have illuminated that NRF2-active macrophages commonly reside in hemorrhagic regions of tumors and that the presence of RBC-heme drives the formation of tumor associated macrophages (TAMs) supportive of tumor growth and invasion which have characteristically high NRF2 and HO-1 and low MHC-II [19]

Autosomal recessive variants (classified as CMT4A) are usually linked to severe, early-onset neuropathy, often appearing during infancy or early childhood

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