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Endolysosomal zinc dysregulation Defects in the endosomeautophagosomelysosome pathway, the major machinery for degrading protein aggregates and damaged organelles, are central drivers of neurodegenerative diseases such as Alzheimers disease, Parkinsons disease and ALS 166

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Mechanisms of pulmonary endothelial barrier dysfunction in acute lung injury and acute respiratory distress syndrome

The total intracellular zinc concentration is estimated to be in the hundreds of micromolar range, yet only a small fraction is exchangeable, with the labile pool maintained at much lower, picomolar levels 28