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References: FDA Mounjaro Approval, FDA Zepbound Approval Indications and Contraindications Approved Uses Type 2 diabetes mellitus (as an adjunct to diet and exercise) Chronic weight management in adults with BMI 30 kg/m, or 27 kg/m with at least one weight-related comorbidity Contraindications Personal or family history of medullary thyroid carcinoma (MTC) Multiple endocrine neoplasia syndrome type 2 (MEN 2) Hypersensitivity to tirzepatide or any component of the formulation Note: Tirzepatide is not indicated for use in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis