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The 5-HT4 receptor, specifically expressed in the prefrontal cortex and limbic system (including the hippocampus and amygdala), regulates learning, memory, and cognitive function [58, 59]
The enzyme is induced by oxidative stress (Pandur et al., 2007, Chikhi et al., 1999, Reuter et al., 2009, DeNicola et al., 2011)
Altered regulation of the HPA axis has been observed in PTSD pathology
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Nrf2 provides protection against cellular damage and -synuclein accumulation [104]
