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Oral administration results in rapid degradation by gastric acid and hepatic first-pass metabolism, rendering the compounds inactive before reaching systemic circulation

Furthermore, effects of cyclic Ta change on Tcore are limited during sleep, and further study is warranted to determine its effects on the wakeful state

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Furthermore, chronic inflammatory processes, and specifically the concentration of TNF-, drive cardiovascular events, such as atherosclerosis, atherothrombotic disease, and venous thromboembolism [27]