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4b), agreeing with previous reports that CHAC1 is an ATF4 target 42,44

It inhibits the pro-survival Akt and ERK1/2 signaling pathways, thereby reducing proliferation and resistance to apoptosis, while also enhancing p53 stability and transcriptional activity, restoring its tumor-suppressive role and promoting hormonally responsive decidualization, a physiological process whose impairment contributes to EMs implantation and persistence (Yu J

Tamura et al., 2007)

Growth hormone receptor gene is expressed in neuropeptide Y neurons in hypothalamic arcuate nucleus of rats

By modulating gene expression, supporting copper-dependent enzyme functions, and promoting extracellular matrix synthesis and anti-inflammatory processes,However, its primary use remains confined to laboratory studies and cosmetic formulations rather than mainstream medical treatments