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Yamakawa H, Kato TS, Noh JY, et al

Long-term effects beyond six months are not well established

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These results indicate that meldonium significantly reduces the size of cerebral infarction, improves neurological function, enhances the motor abilities of MCAO rats, and maintains the morphology and orderly arrangement of neurons in the cerebral cortex and hippocampus

This astrocyte-neuron lactate shuttle initially sustains neuronal ATP synthesis