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Although the exact mechanism is unknown, this rise in melanocyte activity has been shown to be stimulated by prostanoids, cytokines, chemokines, and other inflammatory mediators as well as reactive oxygen species that are released during the inflammatory process

[DOI] [PMC free article] [PubMed] [Google Scholar] 407.Yagi K, et al

The regulation of these metabolic enzymes not only affects cell survival but is also closely associated with the development of various diseases, including cancer and neurodegenerative disorders (77, 78)

Another relevant line of evidence comes from studies of ADHD and allergic rhinitis
