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It acts directly on adipocytes, independently of intake

The 2024 NICE guideline NG239 sets out a more intensive loading schedule for patients with neurological involvement precisely because their starting point is worse

Interestingly, at the end of a three-month follow-up, although both groups showed significant improvements in pain assessed by VAS, the change in the B12 arm was significantly greater relative to the nortriptyline group

The symptoms of B12 deficiency will start showing up after that period. 2
