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6a, b) Delaying G6PDi-1 treatment for 1 h post-stimulation allowed for substantial cytokine production, indicating that G6PD and the PPP likely play an important role in the early signaling events following stimulation

It may also be a by-product of differences in individual cell-line response to the small molecules

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Mayatepek E, Hoffmann GF, Carlsson B, Larsson A, Becker K: Impaired synthesis of lipoxygenase products in glutathione synthetase deficiency