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The endosome is observed to be breached by released folate conjugates by an unidentified mechanism, leading to drug deposition in the cytoplasm
[DOI] [PMC free article] [PubMed] [Google Scholar] Sologub A.A., Akberova S.I., Ziangirova G.G

In a survey of human clinical case studies, 5.3 mg/day was the lowest oral dose at which local gastrointestinal irritation was seen

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